SMART Freeze Drying

SMART Freeze-Dryer Technology is a patented system that puts the experience of the world’s top lyophilization scientists into an easy-to-use cycle development tool. Developed exclusively with leading academics at The University of Connecticut and Purdue University, this technology is available on the LyoStar freeze-dryer (including a retrofit option for existing LyoStar II systems). 

SMART Freeze-Dryer technology eliminates the trial-and-error approach normally involved in developing new lyophilization cycles. It enables experts and novices alike to develop new cycles quickly, while also ensuring that those cycles are elegant and efficient. 

The SMART tools provide instant feedback on important product data — such as product resistance, heat flow, and mass transfer — that was previously unavailable.

Click here to see case studies of how facilities like yours have saved time and money utilizing the LyoStarII with SMART Freeze-DryingTMTechnology

Click here for an overview of the new LyoS software.

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KEY FEATURES
  • SMART Freeze Dryer Technology (PLC) helps automate and shorten the development of the freeze drying cycle
  • Get product information that has previously been unavailable – such as product resistance, heat flow and mass transfer
  • Designed to minimize issues with transfer of freeze drying cycles to your production freeze dryer
  • Easy to use operator interface
  • Condenser coil type configuration to maximize condenser efficiency
  • Available with optional 21 CFR Part 11
  • Clean room configurations available
KEY BENEFITS
  • Substantially decrease cycle development time with SMART
  • Understand more about your product and its obstacles and opportunities in lyophilization cycle development
  • Easily transfer cycles to larger systems
  • Increase ROI with greater throughput and optimized cycles
  • Spend more time looking at formulation strategies to maximize product effectiveness
  • Developed by lyophilization scientists for lyophilization scientists

Specification 
Shelf Temperature Control Range (°C)
-70 to +60C
Lowest Condenser Temperature
-85C
Maximum Condenser Capacity (L)
30 L
Condenser Surface Area (in2 / cm2)
828 / 5481
Maximum Ice Condensing Capacity in 24 hours (L)
This specification is based on freeze drying water as aggessively as possible.  
The ability to collect ice is application dependent and your actual rate will most likely be lower
20
Condenser Pull-Down from 20 °C to -75 °C (minutes)
< 10
Shelf Pull-Down from 20 °C to -40 °C
(minutes)
< 25
Vacuum Time to 100 Millitorr (minutes)
< 20
Lowest System Vacuum (mT)
< 10
Temperature Uniformity (°C)\\
+/- 1.0C


Shelf Configuration
Number of Shelves
Shelf Area
Shelf Clearance
Shelf Clearance with Optional Shelf Latching
 
Bulk and Stoppering** (ft2 / cm2)
Bulk and Stoppering** (in / mm)
1 Shelf Latched (in / mm)
2 Shelves Latched (in / mm)
1 Shelf
1.5 / 1394
9.5 / 241
-
-
2 Shelves
3.1 / 2880
4.5 / 114
9.25 / 235
-
3 Shelves
4.6 / 4274
2.8 / 71
4.25 / 108
8.5 / 216
4 Shelves
6.1 / 5667
2.0 / 51
2.6 / 66
4.0 / 102
5 Shelves
7.6 / 7061
1.5 / 38
-
-


Dimensional Data
Width (in / cm)
33 / 84
Depth (in / cm)
43 / 109
Height (in / cm)
75 / 190
Approximate Weight (lb / kg)
1300 / 590
Minimum Clearance on All Sides (ft / cm)
2 / 61
  • Laboratory research and development and/or small production freeze drying
  • Process development with intent to move process to clinical size freeze dryer
  • Serum bottles and vials