The LyoStar3 is designed to meet the needs
of R&D professionals. Our freeze drying equipment is used for
applications ranging from process development for scale-up to product
processing for stability studies to formulations work. Models are
available in stoppering and bulk configurations.
The LyoStar is an R&D and process
development freeze-dryer that provides unmatched process accuracy,
reliability and unique ease-of-use features. The LyoStar features Type T thermocouple-controlled shelf temperature accuracy of +/- 0.5°C or better and
vacuum control within 0.1% of set-point. Its robust 5.5 hp cascade
refrigeration system enables shelf pull down from ambient to –40°C in
less than 25 minutes, and the ultra-reliable scroll compressors feature
just 3 moving parts.
LyoStar3 is available with Praxair ControLyo™ Nucleation on Demand
Technology. To learn how you can control the nucleation step in freeze
drying view our articles and technical papers on ControLyo™ Nucleation.
Key Features
- SMART Freeze-Dryer Technology helps automate and shorten the development of freeze-drying cycles
- Delivers product information that has previously been unavailable during a cycle - dried layer resistance, heat flow and mass transfer
- Designed to facilitate scale up bu maximizing features in comon with well-designed commercial systems
- Configured with superior instrumentation for complete process information - isolation valve, capacitance manometers, Pirani gauge, 16 thermocouples, Allen Bradley PLC
- Available with 21 CFR Part 11 compliant software and full validation packages
Key Benefits
- Substantially decrease cycle development time and conserves valuable API
- Delivers increased process information such as how different freezing protocols impact cake resistance
- More easily transfer cycles to larger systems
- Maximizes process control, repeatablility
- Meets even the most stringent QA requirements
| Specification |
| Shelf Temperature Control Range (°C) | -70 to +60C |
| Lowest Condenser Temperature | -85C |
| Maximum Condenser Capacity (L) | 30 L |
| Condenser Surface Area (in2 / cm2) | 828 / 5481 |
| Condenser Pull-Down from 20 °C to -75 °C (minutes) | < 10 |
Shelf Pull-Down from 25 °C to -40 °C
(minutes) | < 25 |
| Vacuum Time to 100 Millitorr (minutes) | < 20 |
| Lowest System Vacuum (mT) | < 10 |
| Shelf Surface Temperature Uniformity (°C) | +/- 0.5C |
| Shelf Configuration |
| Number of Shelves | Shelf Area | Shelf Clearance | Shelf Clearance with Optional Shelf Latching |
| | Bulk and Stoppering** (ft2 / cm2) | Bulk and Stoppering** (in / mm) | 1 Shelf Latched (in / mm) | 2 Shelves Latched (in / mm) |
| 1 Shelf | 1.5 / 1394 | 9.5 / 241 | - | - |
| 2 Shelves | 3.1 / 2880 | 4.5 / 114 | 9.25 / 235 | - |
| 3 Shelves | 4.6 / 4274 | 2.8 / 71 | 4.25 / 108 | 8.5 / 216 |
| 4 Shelves | 6.1 / 5667 | 2.0 / 51 | 2.6 / 66 | 4.0 / 102 |
| 5 Shelves | 7.6 / 7061 | 1.5 / 38 | - | - |
| Dimensional Data |
| Width (in / cm) | 33 / 84 |
| Depth (in / cm) | 43 / 109 |
| Height (in / cm) | 78 / 190 |
| Approximate Weight (lb / kg) | 1300 / 590 |
| Minimum Clearance on All Sides (ft / cm) | 2 / 61 |
- Formulation development and stability studies
- Cycle optimization and scale-up
- Lyophilization of product with organic solvents in addition to water
- Laboratory research and development and/or small production freeze drying
- Diagnostic kits
- 96 well plates
- Serum bottles and vials